His first love was music and his instrument was the violin. He pursued a music career and he only turned to mathematics when he was 35 years old. It was Fontaine des Bertins whose enthusiasm for mathematics rubbed off on Vandermonde. Perhaps surprisingly he was elected to the Académie des Sciences in 1771 with little evidence of his mathematical genius other than his first paper which, although he was not a member at the time, was read to the Academy in November 1770. However, he did make quite a remarkable contribution to mathematics in this paper and three further papers which he presented to the Academy between 1771 and 1772. These four papers represent his total mathematical output and we will discuss their content below together with the views of a number of historians of mathematics on his contribution.
Vandermonde's election to the Académie des Sciences did motivate him to work hard for the Academy and to publish other works on science and music. In 1777 he published the results of experiments he had carried out with Bézout and the chemist Lavoisier on low temperatures, in particular investigating the effects of a very severe frost which had occurred in 1776. Ten years later he published two papers on manufacturing steel, this time joint work with Monge and Bertholet. The aim of this research was to improve the steel used for bayonets but experimenting with different mixtures of iron and carbon. That he work closely with Monge reflected the fact that the two were very close friends, in fact he so close that he was known as femme de Monge.
In 1778 Vandermonde presented the first of a two part work on the theory of music to the Académie des Sciences. The second part was presented two years later. This work Système d'harmonie applicable à l'état actuel de la musique Ⓣ did not propose a mathematical theory of music as one might have expected from someone who was an expert in both fields. On the contrary the aim of the work was to put forward the idea that musicians should ignore all theory of music and rely solely on their trained ears when judging music. As one might expect this proved a controversial work with musicians being sharply divided as to whether they agreed with Vandermonde or not. Despite the opposition of many musicians at first, the ideas put forward by Vandermonde gained favour over the years and by the beginning of the nineteenth century the Académie des Sciences had moved music from the mathematical area to the arts area. It is worth repeating that it is strange that a mathematician of the highest rank should have argued against music as a mathematical art, a position it had held since the days of ancient Greece.
Positions which Vandermonde held include director of the Conservatoire des Arts et Métiers in 1782 and chief of the Bureau de l'Habillement des Armées in 1792. In the same year of 1792 he sat with Lagrange on a committee of the Académie des Sciences which had to examine the violon harmonique, a newly invented musical instrument. He was involved with the École Normale, which was founded in October 1794, and was on the team designing a course in political economy. His friend Monge was also involved with the École Normale as were Lagrange and Laplace. However the establishment only operated for six months after it opened in the Muséum d'Histoire Naturelle in January 1795 before being closed down.
Like Monge, Vandermonde was a strong supporter of the Revolution which began with the storming of the Bastille on 14 July 1789. The politics of Revolution in France long before this event had been so exciting for Vandermonde that it diverted him from a possible longer mathematical and scientific career. However the truth of the matter is that he suffered from poor health all his life and, but for this, he might well have been able to be highly involved in politics yet continue with mathematical and scientific activities.
Perhaps the name of Vandermonde is best known today for the Vandermonde determinant. While it is certainly true that he made a major contribution to the theory of determinants, yet nowhere in his four mathematical papers does this determinant appear. It is rather strange, therefore, that this determinant should be named after him and several authors have puzzled over the fact for some time. Lebesgue's conjecture in  (first published in 1940) that it resulted for someone misreading Vandermonde's notation, and therefore believing that this determinant was in his work, seems the most likely.
Vandermonde's four mathematical papers, with their dates of publication by the Académie des Sciences, were Mémoire sur la résolution des équations Ⓣ (1771), Remarques sur des problèmes de situation Ⓣ (1771), Mémoire sur des irrationnelles de différents ordres avec une application au cercle Ⓣ (1772), and Mémoire sur l'élimination Ⓣ (1772).
The first of these four papers presented a formula for the sum of the mth powers of the roots of an equation. It also presented a formula for the sum of the symmetric functions of the powers of such roots. Neither of these were new having appeared in Waring's work shortly before but, although he was aware of this Vandermonde claimed, rightly in my [EFR] opinion, that his approach was sufficiently different to make publication of these results for a second time worthwhile. The paper also shows that if n is a prime less than 10 the equation xn - 1 = 0 can be solved in radicals. Jones writes in :-
... Vandermonde's real and unrecognised claim to fame was lodged in his first paper, in which he approached the general problem of the solubility of algebraic equations through a study of functions invariant under permutations of the roots of the equation.Kronecker claimed in 1888 that the study of modern algebra began with this first paper of Vandermonde. Cauchy states quite clearly that Vandermonde had priority over Lagrange for this remarkable idea which eventually led to the study of group theory.
In his second paper Vandermonde considered the problem of the knight's tour on the chess board. This paper is an early example of the study of topological ideas. Vandermonde considers the intertwining of the curves generated by the moving knight and his work in this area marks the beginning of ideas which would be extended first by Gauss and then by Maxwell in the context of electrical circuits.
In his third paper Vandermonde studied combinatorial ideas. He defined the symbol
The only one fit to be viewed as the founder of the theory of determinants.The reason for this strong claim by Muir is that, although mathematicians such as Leibniz had studied determinants earlier than Vandermonde, all earlier work had simply used the determinant as a tool to solve linear equations. Vandermonde, however, thought of the determinant as a function and gave properties of the determinant function. He showed the effect of interchanging two rows and of interchanging two columns. From this he deduced that a determinant with two identical rows or two identical columns is zero. Finally he gave a remarkably clever notation for determinants which has not survived.
Article by: J J O'Connor and E F Robertson